關於 self assembled ，我們在網路上蒐集到這些相關的討論、資訊與評價

#不維持社交距離 #你就是壞蛋白
#我們只關心壞蛋白有沒有發生_親密接觸👈🚫🈲
#亨丁頓氏舞蹈症 #最新研究
　　
防疫研究是當務之急，罕病研究也需要持續地累積。👍
　　
罕病「亨丁頓氏舞蹈症」(Huntington’s Disease)的病因來自於變異的亨丁頓蛋白(mHtt)異常聚集，堆積在腦部破壞神經元，造成患者腦部神經持續性退化。患者發病後手腳不聽使喚，像在跳舞一樣，末期急速退化，平均存活約15至20年，目前仍無法完全治癒。

中央研究院化學研究所黃人則副研究員與前生醫所杜邦憲助研究員組成的研究團隊，設計出「#雙極性胜肽分子」，能夠將一團團聚集的亨丁頓蛋白分散開來。將此分子透過鼻腔給藥至罹病小鼠後，小鼠的運動與認知功能失調明顯得到改善。
🤜🤜⛏⛏🥚🥚
黃人則表示，雙極性胜肽分子一端可以辨識變異的亨丁頓蛋白並附著上去，另一端帶正電，可以利用電荷排斥力🧲，打散亨丁頓壞蛋白，減少對神經細胞的毒性及損傷。

👉特別的是，此分子的構造和 #肥皂分子 極為相似，想要更科普的說明，可以參考廖院長女兒手繪自製、院長獻聲解說的COVID-19影片，拉到【4:52】為什麼要洗手，也有清楚圖解：https://reurl.cc/620DOy
　　
#這影片好多用途 #感謝應援 💯
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With the increase in the aging population, an effective therapeutic regimen is still an unmet medical need for different neurodegenerative disorders. Dr. Joseph Jen-Tse Huang, an associate research fellow at the Institute of Chemistry in Academia Sinica, Dr. Pang-Hsien Tu, a former assistant research fellow at the Institute of Biomedical Science, and their research teams recently report a self-assembled amphiphilic peptide that can inhibit protein aggregation implicated in the pathogenesis of Huntington’s disease (HD). This new finding was published in Advanced Science on January, 2020.
　　
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📌本研究已於今（2020）年1月刊登於《先進科學》(Advanced Science)
全文: https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201901165　　

📌〈讓「壞蛋白」被分手！雙極性胜肽分子 抑制亨丁頓氏舞蹈症的新策略〉
https://www.sinica.edu.tw/ch/news/6510
　　
📌〈Nanoscopic insights of amphiphilic peptide against Huntington’s disease〉
https://www.sinica.edu.tw/en/news/6510
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📌媒體報導
[中央社] 亨丁頓氏舞蹈症 中研院找到抑制策略
https://www.cna.com.tw/news/ahel/202003190178.aspx

[中國時報]中研院研發雙極性胜肽分子 有助治療亨丁頓氏舞蹈症
https://www.chinatimes.com/realtimenews/20200319002863-260405?ctrack=mo_main_rtime_p08&chdtv

[中央廣播電台] 舞蹈症神經退化壞蛋白 中研院找到抑制策略
https://www.rti.org.tw/news/view/id/2056150

#中研院化學所 #研究成果

BUAKAW invites everyone to join his "Toth Kathin festival" held in Samrong Thap.. Surin Province (Buakaw's hometown ) on 8 November.

After the ceremony there will be fights organized between local fighters and children who love Muay Thai from surrounded areas Surin, Si-Saket , Ubon Ratchathani ..etc.

Everyone is invited ... Don't miss this event ..

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Thot Kathin is a traditional Buddhist festival celebrated in Issan (northeast Thailand), Cambodia, and Laos.

The word Thot means making an offering to the monk and the word Kathin literary means the embroidery frame used in sewing the yellow robes which, in those available in plenty as nowadays. Buddhist people regard the “Thot Kathin” ceremony as the most signification form of merit-making nest to the ordination of their close kin. Thus, once in their lifetime everybody is looking forward to having an opportunity to be the sponsor of a Kathin ceremony as it involves a lot of time manpower and expense.

The origin of "thot kathin'' may briefly be told. During the time of Lord Buddha a group of monks on their way to see the
Lord Buddha had to stop and spend a retreat during the rainy season in a certain town before they could reach their destination.

After the retreat ended the monks hastily left before the rainy season had definitely ended. Wet and muddy on their way,they were a sorry sight when they reached their destination. As monks were not allowed at this time to receive robes from anyone and were expected to make their own robes by washing, cutting
and sewing discarded clothing, the Buddha, seeing the dilemma of
the visiting monks, gave permission for any monk to receive a robe presented by anyone during the month after the retreat.

This is the origin of the "thot kathin" ceremony. Later on when the number of robes presented on these occasions did not suffice for all the monks, the Lord Buddha decided that any monk coming out, of retreat; with a robe more tattered (old and torn) than those of his brethren might receive a robe from any person, provided he be well-versed in the
Buddhist Code of Law and provided the donation be approved by all the assembled monks.

Usually in a village or district there is at least one temple meet for religions festive occasions, and the wat also served them in the past as the peoples' spiritual, intellectual and social center. In the old days a village was a self-contained unit. The people grew their own rice and other kinds of vegetable food, built their own honses and other
things by voluntary and reciprocal aid from their neighbors .
They also wove their own cloth. It was the duty of families to train their daughters in the art. of weaving. A girl who could weave skilfully was the pride of her family. Thus there was no cloth for sale in the village. The annual kathin robe for presentation to a monk had to be woven and made beforehand.

Gift-giving is an act of appreciation and gratitude to the monks. Individuals or community groups (such as a village) may perform them. Many villagers combine efforts by collecting cash donations for the maintenance of their local temple. Such donations are vividly arranged on a "money tree".

The "thot kathin" by the villagers is usually never made to their own village wat, but to the wat of another village.
This is a friendly gesture among the different villages, The "thot kathin" is arranged beforehand. When the day of the "thot kathin'' arrives, the donors of the kathin robe will arrange a procession
with music and other entertainments to accompany the kathin robe which is borne either on a decorated cart or on the back of an elephant.

After the ceremony the people of both villages join in games and pastimes until late in the afternoon when the guests take leave of the hosts who may also present them with fruits and other products of the village.

Easter Brunch ~ Scrambled Eggs in toasted French Croissant. Me perennial favorite on Weekends in Landmark's 置地廣場 Urban Bakery. *This is not on menu, I just order the Eggs & Plain Croissant separately then self assembled.