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#1. Definition of objective response rate - National Cancer Institute
The percentage of people in a study or treatment group who have a partial response or complete response to the treatment within a certain period of time.
#2. Objective response rate assessment in oncology - NCBI
The tumor objective response rate (ORR) is the assessment of the tumor burden (TB) after a given treatment in patients with solid tumors and has a long history.
#3. Objective response rate of placebo in randomized controlled ...
ORR is defined as the percentage of patients who achieve a response, which can either be complete response (complete disappearance of lesions) ...
#4. 美國FDA於2018年12月發表「用於核准抗癌藥品及生物製劑的 ...
(1) 整體存活(Overall survival ， OS) ：定義為在ITT 族群. (intent-to-treat population)中從隨機 ... B. 客觀反應率(Objective response rate，ORR)：定義為腫瘤.
#5. Assessment of objective response rate (ORR) by investigator ...
Of the 40 supporting trials, ORR was the primary endpoint for 21 (52.5%), progression-free survival for 13 (32.5%), and overall survival for 2 ( ...
#6. Efficacy endpoints in Oncology - LexJansen
(TTP), Best Overall Response Rate are some of the key efficacy indicators that ... An example in oncology is the use of objective response rate (ORR) and.
#7. Evaluation of Overall Response Rate and Progression-Free ...
ORR was defined as the proportion of patients who achieved a complete or partial response as their best overall response based on RECIST v1.1 ...
#8. Clinical Trial Endpoints in Cancer Research: Four Terms You ...
Overall response rate, or ORR, is the proportion of patients in a trial whose tumor is destroyed or significantly reduced by a drug.
#9. Objective response rate targets for recurrent glioblastoma ...
Objective response rate (ORR), defined as the proportion of patients with a specific reduction in tumor size sustained over a predefined minimum amount of time, ...
#10. What do clinical trial results mean? | Cancer Research UK
Overall response rate (ORR), The total number of people whose cancer has either gone away (a complete response) or shrunk (a partial ...
#11. Response Rate as a Regulatory End Point in Single-Arm ...
This analysis of 1800 clinical trials in advanced solid tumors identifies circumstances in which a high objective response rate is ...
#12. Clinical Trial Endpoints for the Approval of Cancer Drugs and ...
Pathological Complete Response in Neoadjuvant Treatment of High-Risk ... based on objective response rate (ORR), determined by tumor assessments from ...
#13. Durable response rate as an endpoint in cancer immunotherapy
Consequently, endpoints such as durable response rate (DRR; a continuous response [complete or partial objective response] beginning within ...
#14. Duration of and time to response in oncology clinical trials ...
The best overall response rate (BOR), also called objective response rate, is commonly used in early-stage oncology clinical trials as the primary endpoint.
#15. Is objective response rate (ORR) a valid primary endpoint in ...
The validity of ORR as a surrogate for progression-free survival (PFS) and overall survival (OS) with ICI is uncertain and may differ by tumor type.
#16. pcn24 evaluating the surrogacy of objective response rate for ...
Objectives : Overall survival (OS) is considered the gold-standard primary endpoint in oncology clinical trials. Protective OS treatment effects demonstrate ...
#17. Relationship Between Progression‐Free Survival, Objective ...
Relationship Between Progression-Free Survival, Objective Response Rate, and Overall Survival in Clinical Trials of PD-1/PD-L1 Immune ...
#18. Correlation between treatment effects on response rate and ...
... response rate and progression-free survival and overall survival ... we explored whether improvements in objective response rate (ORR) ...
#19. (PDF) Efficacy endpoints in Oncology - ResearchGate
(TTP), Best Overall Response Rate are some of the key efficacy indicators that ... Best Overall Response Rate or Objective Response Rate (ORR): the presence ...
#20. Statistical Analysis Plan - ClinicalTrials.gov
Objective response rate is defined as the proportion of subjects with best overall response of. CR (complete response) or PR (partial response).
#21. Overall and complete response rates as potential surrogates ...
Aim : The correlation between response and survival has not been well-studied in relapsed or refractory multiple myeloma (RRMM).
#22. Clinical endpoint - Wikipedia
Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of ... Hence the trials report the complete response rate and the overall ...
#23. Confirmation of response in cancer clinical trials
The overall response rate is generally comprised of partial responses sometimes together with a few complete responses. Partial responses are those at ...
#24. Prepare ADaM data sets for Objective Response Rate (ORR ...
Objective Response Rate (ORR) and Progression-free survival (PFS) are commonly used as efficacy endpoints in solid tumor clinical trials.
#25. Overall survival and objective response in advanced ...
Lenvatinib also led to significant improvements in the objective response rate (ORR). ORR by investigator-assessed modified RECIST (mRECIST) for ...
#26. Response rates and minimal residual disease outcomes as ...
Patients with NDMM typically have longer PFS and are more likely to achieve minimal residual disease (MRD) or complete response (CR) ...
#27. Local Investigators Significantly Overestimate Overall ...
Local Investigator Evaluation Versus Blinded Independent Central Review in the Assessment of Relevant Primary Outcomes. Overall Response Rate.
#28. IRC Determines BRUKINSA® (Zanubrutinib) Demonstrates ...
ORR is defined as the combined rate of complete responses (CR) and partial responses (PR). A total of 652 patients were enrolled in the ALPINE ...
#29. A s - Lung Cancer
aNSCLC therapies reporting overall survival (OS), progression-free survival (PFS), and/or objective response rate.
#30. KEYTRUDA® (pembrolizumab) Shows Overall Response ...
KEYTRUDA® (pembrolizumab) Shows Overall Response Rates of 73 to 83 Percent, with Complete Response Rates of 27 to 30 Percent, in Heavily Pre-treated Patients ...
#31. Evaluation bias in objective response rate and disease control ...
Conclusions: Blind independent central review remained irreplaceable to monitor local assessment, but its complete-case implementation may be ...
#32. Kite's Tecartus® CAR T-cell Therapy ... - Gilead Sciences
... -- In CIBMTR Registry Analysis, Tecartus Also Demonstrates 88% Complete Response Rate and 94% Overall Response Rate in ...
#33. A systematic review of meta-analyses assessing the validity of ...
Tumour response endpoints, such as overall response rate (ORR) and complete response (CR), are increasingly used in cancer trials.
#34. Predicting Objective Response Rate (ORR) in Immune ... - MDPI
ICIs are a standard of care in several malignancies; however, according to overall response rate (ORR), only a subset of eligible patients benefits from ...
#35. Extremely High Objective Response Rate of Lenvatinib: Its ...
Extremely High Objective Response Rate of Lenvatinib: Its Clinical Relevance and Changing the Treatment Paradigm in Hepatocellular Carcinoma.
#36. Durable Response Rate
The percent of patients with Complete Response or Partial Response maintained continuously for a minimum of 6 months. 1,2. Key secondary endpoints 1,2. The key ...
#37. Efficacy I PLUVICTO - HCP.Novartis.com
PLUVICTO + BSOC SIGNIFICANTLY IMPROVED OVERALL RESPONSE RATES VS BSOC ALONE 1,3. CR, complete response; ORR, overall response rate; PR, partial response; ...
#38. Response rates nearly double in phase 1 trials of cancer ...
Investigators observed a 12.2% overall response rate and 2.7% complete response rate during the study period. Response rates to investigational ...
#39. 100% Complete Response Rate in 14 Patients With Rectal ...
100% Complete Response Rate in 14 Patients With Rectal Cancer Treated With Neoadjuvant Dostarlimab-gxly · “We were obviously beyond thrilled with ...
#40. Objective response rate assessment in oncology
CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; WHO: World Health Organization; RECIST: Response ...
#41. ASCO 2022: 100% Complete Response Rate in MMRd ...
ASCO 2022: 100% Complete Response Rate in MMRd Locally Advanced Rectal Cancer Seen in Pivotal 'Immunoablative' Neoadjuvant Immunotherapy ...
#42. TECARTUS® Clinical Trial Data for R/R Mantle Cell Lymphoma
Primary analysis. (data cutoff July 24, 2019) 1,4. Response rate (n) [95% Cl]. Objective response rate* 87% (52) [75, 94]. Complete remission rate
#43. Confirmed ORR | ENHERTU® (fam-trastuzumab deruxtecan ...
Find the confirmed objective response rate in patients treated with ENHERTU® ... CR, complete response; ORR, objective response rate; PR, partial response; ...
#44. A Meta-Analysis of Acute Myeloid Leukemia Trials
Background: Response rates such as overall response rate (ORR), complete response (CR) and complete response with incomplete blood recovery (CRi) can be ...
#45. Response to treatment - A Hematology Oncology Wiki
Stable disease rate (SD rate); Unconfirmed complete response rate (CRu rate). RECIST criteria. RECIST 1.1: Eisenhauer EA, Therasse P, Bogaerts J ...
#46. LUMAKRAS® (SOTORASIB) COMBINED WITH VECTIBIX ...
Overall, the confirmed objective response rate (ORR) was 30% in patients with chemo-refractory metastatic colorectal cancer (mCRC).
#47. PD-1 Blockade in Mismatch Repair–Deficient, Locally ...
We assessed the overall response rate using a one-sample ... The percentage of patients with a clinical complete response was 100% (95% ...
#48. CLINICAL TRIAL ENDPOINTS | OncologyPRO
Overall Response Rate (ORR) or reduction of a tumour marker (e.g. PSA response rate). ◇. Progression-free survival (PFS) or percent without progression at ...
#49. Long-term follow-up of MCL patients treated with single-agent ...
The primary end point was overall response rate (ORR). ... The ORR was 67% (23% complete response), with a median duration of response of 17.5 months.
#50. ORR of TRODELVY versus single-agent chemotherapy
Progression-free survival · Overall survival · Objective response rate ... CR=complete response; OR=odds ratio; ORR=objective response rate; PR=partial ...
#51. REVEL Trial Overall Response Rate for mNSCLC - Cyramza
Metastatic Non-Small Cell Lung Cancer. REVEL trial: Overall response rate (ORR). Statistically significant improvement in ORR in the ITT population 1.
#52. Study Shows 33% Objective Response Rate with STRO-002 ...
A folate receptor alpha (FolRα)-targeting antibody-drug conjugate (ADC) for the treatment of patients with advanced ovarian cancer, ...
#53. Unprecedented Response Rate in Advanced Bladder Cancer
The efficacy news was notable. The confirmed response rate with the combination is 73.3%, including 15.6% complete responses and 57.8% partial ...
#54. A Primer on RECIST 1.1 for Oncologic Imaging in Clinical ...
These outcome measures, including objective response rate (ORR) and ... response rate, complete response, and best overall response.
#55. Predicting Objective Response Rate (ORR) in Immune ...
Abstract: ICIs are a standard of care in several malignancies; however, according to overall response rate (ORR), only a subset of eligible ...
#56. STRO-002 Shows 33% Objective Response Rate in Patients ...
The results showed a 33% Objective Response Rate (ORR) in 33 RECIST evaluable patients across all FolRα expression levels.
#57. Dostarlimab Demonstrates 100% Complete Response Rate in ...
Dostarlimab (Jemperli), an anti–PD-1 monoclonal antibody, demonstrated a 100% clinical complete response rate among 14 patients with mismatch ...
#58. [PDF] Objective response rate assessment in oncology
The tumor objective response rate (ORR) is an important parameter to demonstrate the efficacy of a treatment in oncology.
#59. Objective response rate (ORR) targets for recurrent ...
Objective response rate (ORR) targets for recurrent glioblastoma clinical trials based on the historic association between ORR and median overall survival.
#60. 抗腫瘤藥物臨床試驗－常見的療效終點(Endpoints) - 暘氏手札
客觀反應率(Objective response rate, ORR) 定義：腫瘤縮小達先前定義量並 ... 完全反應(Complete Response, CR)：腫瘤在治療後完全消失一段時間。
#61. Early objective response to avelumab treatment is associated ...
with improved overall survival in patients with metastatic Merkel cell carcinoma ... Despite the objective response rates (ORR) to chemo-.
#62. 항암제 1상 통계분석 - LSK Global PS
Objective response rate (ORR) ... Disease Control Rate (DCR) or Clinical Benefit Rate (CBR) ... Best Overall Response using RECIST1.1.
#63. Survival by Depth of Response and Efficacy by International
Objective: To perform an exploratory analysis of overall survival (OS) by ... objective response rate (ORR) compared with sunitinib were.
#64. ASCO GU 2023: Effect of Treatment of Residual Disease After ...
Complete response rates per RECIST v1.1 criteria have varied from 10 to 16%.1,2,3 ... The overall objective response rate was 56% (CR + PR).
#65. New CAR T Therapy Shows 100% Overall Response Rate in ...
New CAR T Therapy Shows 100% Overall Response Rate in Relapsed and Refractory Multiple Myeloma. Posted: Jun 14, 2021. New CAR T Therapy Shows 100% Overall ...
#66. Response Rates for Waldenström Macroglobulinemia Improve ...
That study found that, during the modern era, the proportion of older patients with a complete response or partial response to treatment (known ...
#67. Association between objective response rate and overall ...
The aim was to evaluate objective response rate (ORR) as a predictor of overall survival (OS) in patients with metastatic NETs (mNETs) treated with ...
#68. BRUKINSA® (Zanubrutinib) Demonstrates Superior Objective ...
BRUKINSA ® (Zanubrutinib) Demonstrates Superior Objective Response Rate by Investigator Assessment and Reduced Rates of Atrial Fibrillation or ...
#69. Response rates and pathologic complete response by breast ...
This is the largest study to date evaluating response rates and pathologic complete response (pCR) and predictors thereof, based on ...
#70. Dostarlimab Achieves High Complete Response Rate in ...
Single-agent dostarlimab-gxly elicited a clinical complete response rate of 100% with no evidence of residual tumor in patients with stage ...
#71. Overall response rate - YouTube
Overall vs. Progression-Free Survival, Response Rates : Oncology Terminology 101 (by Oster Oncology). Oster Oncology. Oster Oncology.
#72. In KRYSTAL-1, Adagrasib for NSCLC Has 43% Response Rate
Of note, all 5 complete responses occurred in patients receiving an immune checkpoint inhibitor, 4 of which were in the TTFields arm. Adverse ...
#73. Kite's Tecartus® CAR T-cell Therapy ... - Yahoo Finance
... -- In CIBMTR Registry Analysis, Tecartus Also Demonstrates 88% Complete Response Rate and 94% Overall Response Rate in ...
#74. 'Genexine's cervical cancer DNA vaccine showed 35% overall ...
... showed a 35 percent overall response rate in phase 2 clinical trials. ... evaluation showed a 35 percent objective response rate (ORR), ...
#75. Characterizing a real-world response variable and associated ...
In oncology research, understanding the proportion of patients that experience tumor response (i.e., the response rate) after treatment is ...
#76. RESONATE-2 - Overall Response Rate - Imbruvica
CLL=chronic lymphocytic leukemia, CR=complete response, IRC=independent review committee, iwCLL=International Workshop on CLL, ORR=overall response rate, ...
#77. Ongoing Trial Shows Positive Response Rates With MEK ...
Ongoing Trial Shows Positive Response Rates With MEK Inhibitor Combo ... meaning that these patients had a partial or complete response to ...
#78. Depth of Response Translates Into Real-World Benefit in ...
The overall response rate (ORR) was 73.7%, with 10.9% of patients having a stringent complete response (sCR) and 23.4% having a very good ...
#79. Dostarlimab Demonstrates Promising Response Rates in ...
Dostarlimab Demonstrates Promising Response Rates in Advanced, ... included 23 complete responses (CRs; 16.1%), 42 partial responses (PRs; ...
#80. Kite's Tecartus® CAR T-cell Therapy ... - Kite Pharma
Kite's Tecartus® CAR T-cell Therapy Demonstrates 78% Complete Response Rate and 90% Overall Response Rate in Largest Real-World Evidence ...
#81. TRACON Pharmaceuticals Announces Positive ... - BioSpace
TRACON Pharmaceuticals Announces Positive Results Based on Ongoing Double-Digit Objective Response Rate for Single Agent Envafolimab in the ...
#82. TRACON Pharmaceutical Reports Positive Results Based on ...
The primary endpoint is objective response rate by central review with ... whether TRACON or others will be able to complete or initiate ...
#83. Press Releases | Thursday, Jun 15, 2023 - Genentech
Pivotal study showed durable responses, with a 56% overall response rate, a 43% complete response (remission) rate, and a median duration of ...
#84. FDA Pauses Upifitamab Rilsodotin Trials in Platinum ...
Secondary end points include overall survival, adverse effects, changes in ECOG performance status, objective response rate, and number of ...
#85. GlobeNewswire - WANE 15
TRACON Pharmaceuticals Announces Positive Results Based on Ongoing Double-Digit Objective Response Rate for Single Agent Envafolimab in the ...
#86. tracon pharmaceutica - Market Screener
TRACON Pharmaceuticals Announces Positive Results Based on Ongoing Double-Digit Objective Response Rate for Single Agent Envafolimab in the ...
#87. TRACON Pharmaceuticals Announces Positive Results Based ...
Continuing Double-Digit Objective Response Rate (ORR) by Blinded ... whether TRACON or others will be able to complete or initiate clinical ...
#88. Adagrasib shows promise for the treatment of patients with ...
Additionally, researchers observed a 42% objective response rate (ORR) ... survival (PFS) was 5.4 months, while the median overall survival ...
#89. TRACON Pharmaceuticals Announces Positive Results Based ...
Continuing Double-Digit Objective Response Rate (ORR) by Blinded ... whether TRACON or others will be able to complete or initiate clinical ...
#90. Pembrolizumab plus lenvatinib shows promise in nccRCC
... objective response rate (ORR) in the overall study population was 49% (95% CI, 41%-57%), and best responses included complete response ...
#91. Trial Suggests Optimal Approach to Unresectable CRC Liver ...
The addition of panitumumab did significantly increase the objective response rate (80% vs 53%, P<0.0001), but complete local treatment rate ...
#92. Most Patients With Early-Stage Classical Hodgkin Lymphoma ...
... 100% overall response rate in patents with early-stage classical ... Achieve Complete Response With Brentuximab Vedotin Combination.
#93. FDA places partial hold on Mersana's ovarian cancer therapy ...
The FDA has placed a partial clinical hold pausing enrolment of new ... Investigator-evaluated objective response rate and duration of ...
#94. Elacestrant Shows PFS Benefit For Patients With ER+/HER2 ...
Elranatamab Induces Responses in Patients With Relapsed/Refractory ... the complete response (CR) rates were 0% and 2%, respectively.
#95. Adagrasib Effective for KRAS G12C-Mutant Lung Cancer with ...
Additionally, researchers observed a 42% objective response rate (ORR) ... survival (PFS) was 5.4 months, while the median overall survival ...
#96. Innate Pharma highlights increased lacutamab clinical activity ...
... lacutamab produced an increased global objective response rate (ORR) ... n=21), including 2 complete responses and 7 partial responses.
#97. Journal of Clinical Oncology Publishes Clinical ... - PR Newswire
Results showed an IC objective response rate (ORR) of 42% and IC ... survival was 5.4 months and median overall survival 11.4 months.
overall response rate objective response rate 在 Overall response rate - YouTube 的必吃
Overall vs. Progression-Free Survival, Response Rates : Oncology Terminology 101 (by Oster Oncology). Oster Oncology. Oster Oncology. ... <看更多>