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#11. Nonacidic Farnesoid X Receptor Modulators - ACS Publications

The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR ...

#12. Bile Acid Receptor Farnesoid X Receptor

Bile acid has been well known to serve as a hormone in regulating transcriptional activity of Farnesoid X receptor (FXR), an endogenous bile acid nuclear ...

#13. Expression and activation of the farnesoid X receptor ... - PNAS

The farnesoid X receptor/bile acid receptor (FXR) is a recently discovered member of the nuclear hormone superfamily. FXR ligands have been proposed as ...

#14. Farnesoid X Receptor Agonists Obeticholic Acid and ...

The farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in bile acid homeostasis. FXR agonists, obeticholic acid ...

#15. Microbiota-induced obesity requires farnesoid X receptor - Gut

Farnesoid X receptor (FXR) signalling alters the gut microbiota leading to modulation of glucose metabolism. (A) Principal coordinates analysis plot of ...

#16. Recent advances in the development of farnesoid X receptor ...

Abstract: Farnesoid X receptors (FXRs) are nuclear hormone receptors expressed in high amounts in body tissues that participate in bilirubin metabolism ...

#17. Targeting Farnesoid X receptor (FXR) for developing novel ...

Farnesoid X receptor (FXR) protein, also known as bile acid receptor (BAR), is one such nuclear receptor linked with various cancers. For ...

#18. Suppressing the intestinal farnesoid X receptor/sphingomyelin ...

Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes.

#19. Activated-farnesoid X receptor (FXR) expressed in human ...

The farnesoid X receptor alpha (FXR or NR1H4) is a bile acid sensor, activated by binding to endogenous bile acids (BAs) (e.g., chenodeoxycholic ...

#20. Farnesoid X receptor | 1H. Liver X receptor-like receptors

FXR | HRR1 | RIP14 | Bile acid receptor | FXRα | farnesoid X activated receptor ... FXR is predominantly expressed in liver, intestine, ...

#21. Farnesoid X receptor: from medicinal chemistry to clinical ...

The farnesoid X receptor (FXR) is a bile sensor that acts in coordination with other nuclear receptors to regulate essential steps in bile ...

#22. Role of Farnesoid X Receptor in the Pathogenesis ... - Hindawi

Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal ...

#23. 6HL0: Crystal Structure of Farnesoid X receptor (FXR) with ...

The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired ...

#24. (PDF) Farnesoid X receptor (FXR): Structures and ligands

PDF | Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine.

#25. The identification of farnesoid X receptor modulators as ...

The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids.FXR is a validated pharmacological ...

#26. Farnesoid X Receptor Induces Murine Scavenger ... - PLOS

Farnesoid X receptor (FXR) is a nuclear receptor and a key regulator of liver cholesterol and triglyceride homeostasis.

#27. Farnesoid X receptor signal is involved in deoxycholic acid ...

The farnesoid X receptor (FXR) signaling pathway is known to be involved in the metabolism of bile acid, glucose and lipid.

#28. Farnesoid X Receptor Activation Promotes Hepatic Amino ...

The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, ...

#29. The Farnesoid X Receptor Controls Gene Expression in a ...

Farnesoid X receptor (FXR) is a nuclear receptor for bile acids. Ligand activated-FXR regulates transcription of genes to allow feedback ...

#30. Targeting farnesoid X receptor for liver and metabolic disorders

The farnesoid X receptor (FXR) is a metabolic nuclear receptor expressed in the liver, intestine, kidney and adipose tissue. By regulating the expression ...

#31. The Pathophysiology of Farnesoid X Receptor (FXR) in the GI ...

The Farnesoid-X Receptor, FXR, is a nuclear bile acid receptor. Its originally described function is in bile acid synthesis and regulation within the liver.

#32. The Farnesoid X Receptor Is Expressed in Breast Cancer and ...

The Farnesoid X Receptor Is Expressed in Breast Cancer and Regulates Apoptosis and Aromatase Expression ... Cancer Res (2006) 66 (20): 10120–10126. https://doi.

#33. Bacterial metabolites directly modulate farnesoid X receptor ...

The farnesoid X receptor (FXR), a ligand-activated transcription factor belonging to the adopted orphan receptor, plays an important role in ...

#34. Farnesoid X receptor pathway (Homo sapiens) - WikiPathways

The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates ...

#35. Which medications in the drug class Farnesoid X Receptor ...

The farnesoid X receptor (FXR) is a nuclear receptor expressed in the liver, intestine, kidney, and adipose tissue that regulates a wide variety of target ...

#36. Farnesoid X Receptor activation in brain alters brown adipose ...

Background and Prupose: The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis ...

#37. Farnesoid X receptor - NR1H4 gene & protein - UniProt

Farnesoid X receptor Imported. <p>Information which has been imported from another ... Nuclear receptor subfamily 1, group H, member 4, isoform CRA_aImported.

#38. Study of the Effects of Farnesoid X Receptor (FXR) Ligands on ...

The Farnesoid X receptor (FXR) is a nuclear receptor that controls the transcription of many genes involved in lipid and glucose metabolism.

#39. Intestinal Farnesoid X Receptor and Takeda G Protein Couple ...

FXR and TGR5 are co-expressed in the ileum and colon. These 2 bile acid-activated receptors may cooperate to stimulate GLP-1 secretion and ...

#40. The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of ...

In this study, we report that activation of the farnesoid X receptor (FXR), a member of the ligand-activated nuclear receptor superfamily and ...

#41. Noncanonical farnesoid X receptor signaling inhibits ...

FXR deficiency sensitizes hepatocytes to death receptors (DRs)-engaged apoptosis. FXR overexpression, but not FXR ligands, inhibits apoptosis ...

#42. Farnesoid X Receptor Signaling Shapes the Gut Microbiota ...

The farnesoid X receptor (FXR) plays an important role in mediating the dialog between the host and gut microbiota, particularly through ...

#43. Farnesoid X Receptor Deficiency Improves Glucose ...

The farnesoid X receptor (FXR) is a key regulator of bile acid (BA) metabolism. By promoting BA efflux from the liver, inhibiting hepatic BA ...

#44. Farnesoid X receptor agonist INT-767 attenuates liver ...

Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis Ying-Bin Hu,1 ...

#45. Anti-Farnesoid X Receptor Antibody Products - Biocompare

Farnesoid X Receptor is a reported alias name for the human gene NR1H4, or 'nuclear receptor subfamily 1 group H member 4'. The 486-amino acid ...

#46. Farnesoid X receptor and fibroblast growth factor 15/19 as ...

Abstract. The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed ...

#47. Mouse Farnesoid X Receptor Reporter Assay System

Features. Screen test samples to quantify functional activity, either agonist or antagonist, that they may exert against mouse FXR; Robust technology ...

#48. How Do Farnesoid X Receptor Agonists Work? - RxList

Farnesoid X receptor (FXR) agonists are a semi-synthetic bile acid analog used to treat primary biliary cholangitis (PBC) in adult patients with inadequate ...

#49. Natural Products as Farnesoid X Receptor (FXR) Agonists

Nuclear receptors (NRs) are ligand-activated transcription factors modulating significant biological functions including cell growth, lipid metabolism, an.

#50. FXR - Intercept Pharmaceuticals

FXR, a nuclear receptor expressed in the liver and intestine, is a key regulator of bile acid, inflammatory, fibrotic and metabolic pathways. Understanding FXR.

#51. Inhibition of farnesoid X receptor signaling shows beneficial ...

In the paper titled ''Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity'' Mueller et al.

#52. Farnesoid X receptor: An important factor in blood glucose ...

Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid ...

#53. Synthesis and discovery of andrographolide derivatives as ...

Based upon the discovery of the natural compound andrographolide (1) as a non-steroidal farnesoid X receptor (FXR) antagonist, a series of andrographolide ...

#54. Farnesoid X Receptor Agonist as a new treatment option for ...

Results: One such option is using agonists of the farnesoid X receptor (FXR) which are nuclear receptors abundantly expressed in the liver and shown to play a ...

#55. FXR | Farnesoid X Receptor - Selleck Chemicals

FXR agonists are available at Selleck. Check Farnesoid X Receptor signaling reviews and assay information.

#56. Loss of functional farnesoid X receptor increases ...

The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid ...

#57. A synthetic farnesoid X receptor (FXR) agonist promotes ...

farnesoid x receptor (FXR, also referred to as NR1H4) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. Bile acids, the ...

#58. The role of farnesoid X receptor in metabolic diseases, and ...

Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic ...

#59. Transactivation and Coactivator Recruitment Assays for ...

The farnesoid X receptor (FXR) is a nuclear receptor responsible for homeostasis of bile acids, lipids, and glucose. Compounds that alter endogenous FXR ...

#60. Farnesoid X Receptor Agonism Protects against Diabetic ...

Additionally, TUDCA activates the farnesoid X receptor (FXR), which is highly expressed in tubular cells. We hypothesized that TUDCA ameliorates maladaptive ...

#61. Farnesoid X receptor agonist Treatment of hepatobiliary and ...

Tropifexor (LJN-452) is a highly potent, novel, non-bile acid farnesoid X receptor (FXR) agonist that is currently being evaluated for hepatobiliary and ...

#62. On the Evolution of Bile Salts and the Farnesoid X Receptor in ...

In particular, it has been realized that the response of the farnesoid X receptor (FXR) to bile acids provides a signal bridge between the ...

#63. Farnesoid X Receptor Agonists | DrugBank Online

A bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance ...

#64. Impaired Intestinal Farnesoid X Receptor Signaling in Cystic ...

Background & Aims. The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the ...

#65. Farnesoid x receptor (fxr) and intestinal mucosa - Slideshare

Bile acids activated receptors regulate the integrity of gastrointestinal mucosa focus on FXR. Stefano Fiorucci, MD Department of Surgical and Biomedical ...

#66. New key publication:Intestinal Farnesoid X Receptor Controls ...

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. PX20606 (PX) activates FXR in the intestine, ...

#67. Nuclear receptors as never seen before: LXR (LIVER X ...

Liver X receptors (LXRs) are ligand-dependent transcription factors that regulate gene expression of genes that play a crucial role in the ...

#68. Targeting Farnesoid X receptor with Obeticholic acid - DocMode

An online lecture on Targeting Farnesoid X receptor with Obeticholic acid : Hype or Hope on DocMode. An online Lecture on Hepatology.

#69. Carroceria; LOGO GILERA RUNN FX/FXR PVGRI. SHOP ...

This free Logos design of fxr Logo EPS has been published by PNGLogos. ... 'Farnesoid X receptor' is one option -- get in to view more @ The Web's largest ...

#70. Lipid Signaling and Metabolism - 第 424 頁 - Google 圖書結果

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid ... Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) ...

#71. Diabetes: Advances in Research and Treatment: 2011 Edition

“Our previous studies have shown that the farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, modulates renal SREBP-l expression.

#72. Signaling Pathways in Liver Diseases - 第 397 頁 - Google 圖書結果

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and ... Farnesoid X‐receptor activates transcription of the phospholipid pump MDR3.

#73. Successful Drug Discovery, Volume 3 - 第 241 頁 - Google 圖書結果

113 Mencarelli, A., Renga, B., Distrutti, E., and Fiorucci, S. (2009) Antiatherosclerotic effect of farnesoid X receptor. Am. J. Physiol. Heart Circ.

#74. Non-Alcoholic Fatty Liver Disease: A 360-degree Overview

Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today. 2012;17:988–97. 37.

#75. Nuclear Receptors: Current Concepts and Future Challenges

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. ... Natural structural variants of the nuclear receptor farnesoid X receptor affect ...

#76. Molecular signatures of long-term hepatocellular carcinoma ...

... receptor signaling, for example, the farnesoid X receptor (FXR) pathway, were down-regulated in association with high-risk PLS-NAFLD.

#77. Terns Pharmaceuticals Highlights Clinical Data from Multiple ...

Data are also being presented from the Phase 2a LIFT study of TERN-101, the Company's liver-distributed farnesoid X receptor (FXR) agonist.

#78. Gilead to Present Latest Data From Across Liver Disease ...

Safety and Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor in a Proof-of-Concept Study in Patients With Compensated Cirrhosis ...

#79. Terns Pharmaceuticals Highlights Clinical Data ... - StreetInsider

... “Multiple doses of thyroid hormone receptor-beta agonist TERN-501 ... Company's liver-distributed farnesoid X receptor (FXR) agonist.

#80. 2022-06-22 | NDAQ:TERN | Press Release - Stockhouse

Data are also being presented from the Phase 2a LIFT study of TERN-101, the Company's liver-distributed farnesoid X receptor (FXR) agonist.

#81. Search: authors:"Xu, H. Eric" - Paperity

Receptor binding studies show that the Omicron BA.2 spike trimer exhibits ... The bile acid (BA)-sensing nuclear receptor, farnesoid X receptor (FXR), ...

#82. PPAR-alpha agonist treatment increases trefoil factor family-3 ...

Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflamma- tory response. Hepatology 2008; 48: 1632-43. 11. De Bosscher K, Haegeman G.

#83. Receptor X farnesoide FunciónyInteracciones

El receptor de ácidos biliares ( BAR ), también conocido como receptor farnesoide X ( FXR ) o NR1H4 (subfamilia 1 del receptor nuclear, grupo H, miembro 4), ...

#84. Cellular Signaling in Health and Disease - 第 97 頁 - Google 圖書結果

Receptors,. and. Farnesoid. X. Receptors. Regulate. Transcription ... operate together with the liver X receptors (LXRs) and farnesoid X receptor (FXR) to ...

#85. Virtual Drug Design - 第 197 頁 - Google 圖書結果

against FXR exhibited partially similar binding interactions to those of the ... Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and ...

#86. Cureus | Coevolution of the Human Host and Gut Microbiome

... acid membrane receptors, in particular, nuclear farnesoid-activated X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5), ...

#87. Intercept Announces PBC Data Presentations at The

OCALIVA, a farnesoid X receptor (FXR) agonist, is indicated for the treatment of adult patients with primary biliary cholangitis (PBC).

#88. The Liver: Biology and Pathobiology - 第 375 頁 - Google 圖書結果

Farnesoid X receptor activation promotes hepatic amino acid catabolism and ammonium clearance in mice. Gastroenterol, 2017;152:1462–76. 13.

#89. Intercept Announces PBC Data P - GuruFocus.com

OCALIVA, a farnesoid X receptor (FXR) agonist, is indicated for the treatment of adult patients with primary biliary cholangitis (PBC).

#90. Clinical and Population Studies - CiteSeerX

tional low-density lipoprotein receptor (LDLR) alleles have ... such as the estrogen and farnesoid X receptors, transforming.

#91. 無題

Although all act via insect nicotinic acetylcholine receptors, ... farnesoid X receptor (FXR AMG-410 serves as a proof-of-concept that NMR-guided drug ...

#92. Pharmacological Control Of Lipid Metabolism Copy - staging

receptor (FXR). However, farnesol's effects on human hepatic lipid metabolism are currently unknown. The objective of this study is to ...

#93. The Biliary System, Second Edition - SoftArchive – SANET

... and the farnesoid X receptor (FXR) pathways, respectively. ... by rapidly activating nuclear receptors and cell signaling pathways.